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Stem Cell Transplantation after...

CardiologieSTEM CELLS TRANSPLANTATION AFTER LATE REPERFUSION IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION


Articol din publicatia Timisoara Medical Journal nr. 3/2005
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Bogdan Mut-Vitcu, Stefan I. Dragulescu, Virgil Paunescu, Daniela L. Popa, Adina Ionac, Simona Popa, Milovan Slovenski, Petre Deutsch, Erika Deak, Calin Tatu, Valentin Ordodi, Adriana Plesa, Simona Dragan, Andreea Dragulescu, Daniela Maximov, Mircea Crisnic, Marius Sintean, Horia Cioloca, Dan Gaita, Mirela Tomescu, Marius Blendea

Introduction: Experimental and clinical studies suggest that transplantation of bone marrow derived stem cells (BMC) beneficially affect left ventricular (LV) remodeling process after acute myocardial infarction (MI) and contribute to the regeneration and neovascularization of ischemic myocardium. Objective: To assess the safety and feasibility of autologous transplantation by intracoronary infusion of AC133+ BMC in patients with acute or recent MI.

Methods: Patients with successful late reperfusion and stent implantation for acute or recent, large MI (LV ejection fraction (EF)

Results: No major periprocedural complications occurred. After 1 and 3 months all patients were free of angina and arrhythmias. After 3 months we have noticed significant decrease of perfusion defect detected by MIBI-scan (perfusion defect extent: 29.414.9% vs 36.312.3%, p

Conclusions: Our results suggest that autologous BMC transplantation by intracoronary infusion proves to be a safe and feasible method, with potential of myocardial function improvement.
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