Dendritic cells - a potential tool for tolerance induction in organ transplantation
Articol din publicatia Timisoara Medical Journal
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Authors: Lucian P. Jiga1, Janina Jiga2
1Pius Branzeu Center for Laparoscopic Surgery and Microsurgery, 2Department of Immunology, Victor Babes University of Medicine and Pharmacy, Timisoara
Dr. Lucian P. Jiga, Pius Branzeu Center for Laparoscopic Surgery and Microsurgery, P-ta Eftimie Murgu, Nr. 2, Timisoara, Romania,
Dendritic cells (DCs) represent a complex system of uniquely-equipped antigen presenting cells that control both initiation and modulation of the immune responses. Extensive studies documented well the crucial role of DCs not only as triggers of the primary immune activation but also in the induction of the immunological tolerance. Although further research will be needed to fully understand the DC biology, artificial manipulation of DCs, for antigen-specific suppression the immune system, offers a tremendous potential as future therapy of allograft rejection in organ transplantation or autoimmune disease. In this brief review, the actual principles for generating the so-called "tolerogenic" DCs, as well as different outcomes reported after using such cells in experimental models, will be outlined.
Key words: Dendritic cells, immunological tolerance, innate immunity, allograft rejection, T-cell response.